latrophilin-2 (Ca+2-independent alpha-latrotoxin receptor 2, latrophilin homolog 1, lectomedin-1, LPHN2, KIAA0786, LEC1, LPHH1)

Function

• low affinity Ca+2-independent receptor for alpha-latrotoxin
• regulation of exocytosis (putative).
• proteolytically cleaved into 2 subunits
  • a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85)

Alternative splicing

named isoforms=4

Expression

• expressed widely in normal tissues

Pathology

• expression is variable in tumor cell lines, elevated in some, absent or markedly diminished in others

More general terms

• latrophilin

Database

• OMIM: https://mirror.omim.org/entry/607018
• UniProt: http://www.uniprot.org/uniprot/O95490.html