lithostathine-1-alpha; islet cells regeneration factor; ICRF; islet of Langerhans regenerating protein; REG; pancreatic stone protein; PSP; pancreatic thread protein; PTP; regenerating islet-derived protein 1-alpha; REG-1-alpha; regenerating protein 1 alpha (REG1A, PSPS, PSPS1, REG)

Function

• might act as an inhibitor of spontaneous Ca+2 carbonate precipitation
• may be associated with neuronal sprouting in brain, & with brain & pancreas regeneration

Structure

• the composition of the O-linked carbohydrate on Thr-27 is complex & varied
• in the crystallographic structure, the attached sugar appears to be N-acetylglucosamine, typical of an intracellular protein, rather than N-acetylgalactosamine
• contains 1 C-type lectin domain

Compartment

secreted

Expression

• expressed in pancreatic acinar cells
• expressed, at lower levels, in brain
• high expression levels in fetal & infant brains
• much lower in adult brains

Pathology

• enhanced expression of REG1A-related transcripts & intraneuronal accumulation of REG1A-like proteins is found in brain from patients with Alzheimer disease & Down's syndrome

Laboratory

• pancreatic stone protein in serum/plasma

More general terms

• lithostathine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5967
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5967
• OMIM: https://mirror.omim.org/entry/167770
• UniProt: http://www.uniprot.org/uniprot/P05451.html