intestinal maltase glucoamylase [includes: maltase (alpha-glucosidase); glucoamylase (glucan 1,4-alpha-glucosidase)] (MGAM, MGA, MGAML)

Function

• may serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is diminished because of immaturity or malnutrition
• may play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing
• does not undergo intracellular or extracellular proteolytic cleavage
• hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose
• hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose

Structure

• monomer
• N- & O-glycosylated
• sulfated (putative)
• belongs to the glycosyl hydrolase 31 family
• contains 2 P-type (trefoil) domains

Compartment

• apical cell membrane, brush border

Expression

• expressed in small intestine, granulocyte, & kidney but not in salivary gland or pancreas

More general terms

• glucosidase
• amylase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8972
• OMIM: https://mirror.omim.org/entry/154360
• UniProt: http://www.uniprot.org/uniprot/O43451.html