troponin I, fast skeletal muscle; troponin I, fast-twitch isoform (TNNI2)

Function

• troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers Ca+2 sensitivity to striated muscle actomyosin ATPase activity
• binds to actin & tropomyosin

Structure

belongs to the troponin I family

Pathology

• defects in TNNI2 are a cause of distal arthrogryposis type 2B

More general terms

• troponin-I

Additional terms

• troponin

Database

• UniProt: http://www.uniprot.org/uniprot/P48788.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7136
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7136
• OMIM: https://mirror.omim.org/entry/191043
• OMIM: https://mirror.omim.org/entry/601680