GTP-binding regulatory protein beta-4; transducin beta-4 (GNB4)

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^[1]^[2]^[3]

Function

G-beta & G-gamma chains are required for
- GTPase activity of heterotrimeric G proteins
- replacement of GDP by GTP
- G protein-effector interaction

Structure

G proteins are composed of 3 units G-alpha, G-beta & G-gamma
belongs to the WD repeat G protein beta family
contains 7 WD repeats

Expression

found in brain & lung^[1]
nearly ubiquitously expressed ^[2]
strongly expressed in lung & placenta^[3]
weakly expressed in brain & heart^[3]

More general terms

GTP-binding regulatory protein beta

Additional terms

References

↑ ^1.0 ^1.1 Simon MI, Strathmann MP, Gautam N. Diversity of G proteins in signal transduction. Science. 1991 May 10;252(5007):802-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1902986
↑ ^2.0 ^2.1 Hepler JR & Gilman AG G proteins TIBS 17:383 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1455506
↑ ^3.0 ^3.1 ^3.2 UniProt http://www.uniprot.org/uniprot/Q9HAV0.html

Database

Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=59345
Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:59345
OMIM: https://mirror.omim.org/entry/610863
UniProt: http://www.uniprot.org/uniprot/Q9HAV0.html

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