monoamine oxidase [MAO]-B
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Function
- catalyzes oxidative deamination of biogenic & xenobiotic amines
- role in metabolism of neuroactive & vasoactive amines in the central nervous system & peripheral tissues
- MAOB preferentially degrades benzylamine & phenylethylamine
RCH(2)NH(2) + H2O + O2 <--> RCHO + NH3 + H2O2
Cofactor: FAD
Structure
- monomer, homodimer or heterodimer (containing two subunits of similar size)
- each subunit contains a covalently bound flavin
- enzymatically active as monomer (putative)
- belongs to the flavin monoamine oxidase family
Compartment
mitochondrial outer membrane, cytoplasmic side
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P27338.html
- ↑ SHMPD, The Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=MAOB
- ↑ Wikipedia, monoamine oxidase entry http://en.wikipedia.org/wiki/monoamine_oxidase