nardilysin; N-arginine dibasic convertase; NRD convertase; NRD-C (NRD1)

Function

• cleaves peptide substrates on the N-terminus of Arg in dibasic pairs
• hydrolysis of polypeptides, preferably at -Xaa-|-Arg-Lys-, & less commonly at -Arg-|-Arg-Xaa-, in which Xaa is not Arg or Lys

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

belongs to the peptidase M16 family

Alternative splicing

named isoforms=2

Expression

• primarily in adult heart, skeletal muscle, & testis & at much lower levels in other tissues

More general terms

• metalloprotease
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4898
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4898
• OMIM: https://mirror.omim.org/entry/602651
• UniProt: http://www.uniprot.org/uniprot/O43847.html