cysteine & glycine-rich protein 3; cysteine-rich protein 3; CRP3; cardiac LIM protein; LIM domain protein, cardiac; muscle LIM protein (CSRP3, CLP, MLP)

Function

• positive regulator of myogenesis
• could play a role in mechanical stretch sensing
• interacts with LDHD (putative)

Structure

• contains 2 LIM Zn+2-binding domains

Compartment

• nucleus (putative)
• cytoplasm, cytoskeleton (putative)
• nuclear, associates with the actin cytoskeleton (putative)

Expression

• cardiac muscle & slow-twitch skeletal muscles

Pathology

• defects in CSRP3 are the cause of
  • cardiomyopathy dilated type 1M
  • cardiomyopathy familial hypertrophic type 12

Notes

also see cysteine-rich protein 3

More general terms

• LIM domain protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8048
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8048
• OMIM: https://mirror.omim.org/entry/600824
• OMIM: https://mirror.omim.org/entry/607482
• OMIM: https://mirror.omim.org/entry/612124
• UniProt: http://www.uniprot.org/uniprot/P50461.html