beta-2-glycoprotein 1; APC inhibitor; activated protein C-binding protein; anticardiolipin cofactor; apolipoprotein H; apo-H; beta-2-glycoprotein I; B2GPI; beta(2)GPI (APOH, B2G1)

Function

• binds to various kinds of negatively charged substances such as heparin, phospholipids, & dextran sulfate
• may prevent activation of the intrinsic coagulation cascade by binding to phospholipids on the surface of damaged cells

Structure

• N- & O-glycosylated
• contains 4 Sushi (CCP/SCR) domains

Compartment

secreted

Expression

• expressed in liver & secreted into plasma

Pathology

• autoantibody in antiphospholipid syndrome

Laboratory

• beta-2 glycoprotein-1 Ab in serum
  • beta-2 glycoprotein-1 IgA in serum
  • beta-2 glycoprotein-1 IgG in serum
  • beta-2 glycoprotein-1 IgM in serum

More general terms

• apolipoprotein
• beta 2 globulin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=350
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:350
• OMIM: https://mirror.omim.org/entry/138700
• UniProt: http://www.uniprot.org/uniprot/P02749.html