phosphatidate phosphatase LPIN3; lipin-3; lipin-3-like (LPIN3, LIPN3L)

Function

• regulates fatty acid metabolism
• Mg+2-dependent phosphatidate phosphatase
• catalyzes conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine & phosphatidylethanolamine biosynthesis
• inhibited by N-ethylmaleimide (putative)

Cofactor: Mg+2 (putative)

Structure

• contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity
• contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif (putative)
• belongs to the lipin family

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

• expressed in intestine & other regions of the GI tract

More general terms

• lipin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64900
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64900
• OMIM: https://mirror.omim.org/entry/605520
• UniProt: http://www.uniprot.org/uniprot/Q9BQK8.html