Rho guanine nucleotide exchange factor 10 (ARHGEF10, KIAA0294)

Function

• may play a role in developmental myelination of peripheral nerves

Structure

contains 1 DH (DBL-homology) domain

Alternative splicing

named isoforms=5

Pathology

• defects in ARHGEF10 are the cause of slowed nerve conduction velocity

More general terms

• rho guanine nucleotide exchange factor
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9639
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9639
• OMIM: https://mirror.omim.org/entry/608136
• OMIM: https://mirror.omim.org/entry/608236
• UniProt: http://www.uniprot.org/uniprot/O15013.html