SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2; 60 kD BRG-1/Brm-associated factor subunit B; BRG1-associated factor 60B; BAF60B (SMARCD2, BAF60B, PRO2451)

Function

• role in transcriptional activation & repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology)
• component of the BAF complex

Structure

• belongs to the SMARCD family
• contains 1 SWIB domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in liver, lung, muscle, pancreas & placenta

More general terms

• SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily D
• BRG1 associated factor
• nuclear protein
• phosphoprotein

Component of

• SWI/SNF-A (BAF) chromatin remodeling complex

Database

• OMIM: https://mirror.omim.org/entry/601736
• UniProt: http://www.uniprot.org/uniprot/Q92925.html