DNA-binding protein SATB2; special AT-rich sequence-binding protein 2 (SATB2, KIAA1034)

Function

• palate formation
• belongs to the CUT homeobox family
• contains 2 CUT DNA-binding domains
• contains 1 homeobox DNA-binding domain

Compartment

nucleus

Expression

• expressed in adult brain > fetal brain > adult liver, kidney, spinal cord
• in brain, expressed in amygdala, corpus callosum, caudate nucleus, hippocampus

Pathology

• chromosomal translocations t(2;7); t(2;11) involving SATB2 are found in isolated cleft palate

More general terms

• DNA-binding protein

Database

• OMIM: https://mirror.omim.org/entry/608148
• UniProt: http://www.uniprot.org/uniprot/Q9UPW6.html