macrophage-capping protein; actin regulatory protein CAP-G (CAPG AFCP MCP)

Function

• Ca+2-sensitive protein
• reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments
• may play role in macrophage function
• may play role in regulating cytoplasmic &/or nuclear structures through potential interactions with actin
• may bind DNA

Structure

• the N-terminus is blocked
• belongs to the villin/gelsolin family
• contains 3 gelsolin-like repeats

Compartment

• cytoplasm, nucleus
• melanosome, stage 1 to stage 4

Expression

macrophages & macrophage-like cells

Notes

• originally thought to be a DNA-binding protein with a helix-loop-helix domain

More general terms

• DNA-binding protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P40121.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=822
• OMIM: https://mirror.omim.org/entry/153615