secretogranin-1; chromogranin-B; CgB; secretogranin I; SgI; contains: GAWK peptide; CCB peptide (CHGB, SCG1)

Function

• neuroendocrine secretory granule protein
• may be the precursor for other biologically active peptides
• extensively processed by limited proteolysis at conserved basic residues
• alternative processing are seen in different tissues (putative)

Structure

• belongs to the chromogranin/secretogranin protein family

Compartment

• secreted
• neuroendocrine & endocrine secretory granules

Expression

• expressed in the adrenal medulla, & in pheochromocytoma
• not expressed in liver

More general terms

• chromogranin; secretogranin;granin
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1114
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1114
• OMIM: https://mirror.omim.org/entry/118920
• UniProt: http://www.uniprot.org/uniprot/P05060.html