spectrin beta chain, erythrocyte; beta-I spectrin (SPTB SPTB1)

Function

• beta subunit of spectrin
• phosphorylated
  • first phosphorylation event occurs on Ser-2114, followed by Ser-2125, Ser-2123, Ser-2128, Ser-2117, & Thr-2110

Structure

• belongs to the spectrin family
• contains 2 CH (calponin-homology) domains
• contains 17 spectrin repeats

Compartment

• cytoplasm, cytoskeleton, cell cortex

Alternative splicing

named isoforms=3

Pathology

• defects in SPTB are the cause of
  • elliptocytosis type 3
  • hereditary spherocytosis type 1

More general terms

• beta-spectrin

Database

• UniProt: http://www.uniprot.org/uniprot/P11277.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6710
• OMIM: https://mirror.omim.org/entry/130600
• OMIM: https://mirror.omim.org/entry/182870