troponin T, fast skeletal muscle; TnTf; Fast skeletal muscle troponin T; fTnT; beta TnTF (TNNT3)

Function

• troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers Ca+2 sensitivity to striated muscle actomyosin ATPase activity

Structure

belongs to the troponin T family

Alternative splicing

named isoforms=7 additional isoforms seem to exist

Expression

• expressed in fetal & adult fast skeletal muscles
• higher level expression in fetal than in adult muscle

Pathology

• defects in TNNT3 are a cause of arthrogryposis multiplex congenita, distal, type 2B

More general terms

• troponin-T

Additional terms

• troponin

Database

• UniProt: http://www.uniprot.org/uniprot/P45378.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7140
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7140
• OMIM: https://mirror.omim.org/entry/600692
• OMIM: https://mirror.omim.org/entry/601680