troponin T, slow skeletal muscle; TnTs; slow skeletal muscle troponin T; sTnT (TNNT1, TNT)

Function

• troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers Ca+2 sensitivity to striated muscle actomyosin ATPase activity

Structure

belongs to the troponin T family

Alternative splicing

named isoforms=3

Pathology

• defects in TNNT1 are the cause of nemaline myopathy type 5; a nucleotide replacement in exon 11 causes the protein to be truncated after residue 178

More general terms

• troponin-T

Additional terms

• troponin

Database

• UniProt: http://www.uniprot.org/uniprot/P13805.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7138
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7138
• OMIM: https://mirror.omim.org/entry/191041
• OMIM: https://mirror.omim.org/entry/605355