phosphatase-2A 55 kD regulatory subunit B alpha; PP2A subunit B-B-alpha isoform; PP2A subunit B,-B55-alpha isoform; PP2A subunit B-PR55-alpha isoform; PP2A subunit B-R2-alpha isoform (PPP2R2A)

Function

• several forms of phosphatase 2A B subunit encoded by separate genes are found complexed with a single catalytic & A subunit
• B regulatory subunit might modulate substrate selectivity & catalytic activity, & also might direct the localization of the catalytic enzyme to a particular subcellular compartment
• PP2A-B subunit appears to suppress the activity of PP2A
• ceramide activates heterotrimeric PP2A, but not PP2A-catalytic monomer or PP2A-cat/PP2A-A heterodimer
• binding of ceramide is suggested to inhibit PP2A-B inhibition of PP2A

Structure

• N-terminus is blocked
• belongs to the phosphatase 2A regulatory subunit B family
• contains 7 WD repeats

Expression

In all tissues examined

More general terms

• phosphatase-2A B subunit

Additional terms

• phosphatase-2A (ceramide-activated protein phosphatase)

Database

• UniProt: http://www.uniprot.org/uniprot/P63151.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5520
• OMIM: https://mirror.omim.org/entry/604941