DNA-directed RNA polymerases I & 3 subunit RPAC2 (RNA polymerases 1 & 3 subunit AC2, DNA-directed RNA polymerase I subunit D, DNA-directed RNA polymerase 1 16 kD polypeptide, RPA16, RPC16, hRPA19, AC19, POLR1D)

Function

• subunit of DNA-dependent RNA polymerase 1 & RNA polymerase 3 which synthesize ribosomal RNA precursors & small RNAs, such as 5S rRNA & tRNAs,respectively
• the RNA polymerase 1 & RNA polymerase 3 complexes consists of at least 13 & 17 subunits, respectively

Structure

• belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family

Compartment

nucleus

Alternative splicing

named isoforms=2

• isoform 1 contains an RNA polymerase domain & has DNA-dependent RNA polymerase activity
• isoform 2 does not have an an RNA polymerase domain or RNA polymerase activity

Pathology

• defects in POLR1D are the cause of Treacher-Collins syndrome 2

More general terms

• rna polymerase subunit

Component of

• RNA polymerase 1
• RNA polymerase 3

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51082
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51082
• OMIM: https://mirror.omim.org/entry/613715
• OMIM: https://mirror.omim.org/entry/613717
• UniProt: http://www.uniprot.org/uniprot/P0DPB6.html
• UniProt: http://www.uniprot.org/uniprot/Q9Y2S0.html
• UniProt: http://www.uniprot.org/uniprot/P0DPB5.html