laminin beta-3 (nicein alpha, kalinin B1 chain, BM600, laminin B1k, LAMB3 LAMNB1)

Function

• laminin beta
• subunit of laminin-5 (epiligrin/kalinin/nicein)

Structure

• the alpha-helical domains I & II are thought to interact with other laminin chains to form a coiled coil structure
• domain VI is globular
• contains 6 laminin EGF-like domains
• contains 1 laminin N-terminal domain

Compartment

• secreted, extracellular space, extracellular matrix
• basement membrane

Expression

found in the basement membranes (major component)

Pathology

• defects in LAMB3 are a cause of
  • epidermolysis bullosa junctional Herlitz type
  • generalized atrophic benign epidermolysis bullosa
  • amelogenesis imperfecta 1A

Laboratory

• LAMB3 gene mutation

More general terms

• laminin-beta (laminin B1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3914
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3914
• OMIM: https://mirror.omim.org/entry/104530
• OMIM: https://mirror.omim.org/entry/150310
• OMIM: https://mirror.omim.org/entry/226650
• OMIM: https://mirror.omim.org/entry/226700
• UniProt: http://www.uniprot.org/uniprot/Q13751.html