laminin beta-2 (laminin-S, laminin B1s, LAMB2, LAMS)

Function

• laminin beta
• subunit of laminin-3 (S-laminin), laminin-4 (S-merosin), & laminin-7 (KS-laminin)

Structure

• alpha-helical domains I & II are thought to interact with other laminin chains to form a coiled coil structure
• domains VI & IV are globular
• contains 13 laminin EGF-like domains
• contains 1 laminin IV type B domain
• contains 1 laminin N-terminal domain

Compartment

• secreted, extracellular space, extracellular matrix
• basement membrane
• concentrated in the synaptic cleft of the neuromuscular junction

Pathology

• defects in LAMB2 are the cause of
  • microcoria-congenital nephrotic syndrome
  • congenital nephrotic syndrome

More general terms

• laminin-beta (laminin B1)

Component of

• laminin-3 (S-laminin)
• laminin-4 (S-merosin)
• laminin-7 (KS-laminin)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3913
• OMIM: https://mirror.omim.org/entry/150325
• UniProt: http://www.uniprot.org/uniprot/P55268.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3913