gamma-aminobutyric acid receptor subunit pi; GABA(A) receptor subunit pi (GABRP)

Function

• GABA-A receptor subunit
• in the uterus, the function of the receptor appears to be related to tissue contractility
• binding of GABRP with other GABA-A receptor subunits alters sensitivity of recombinant receptors to modulatory agents such as pregnanolone
• may bind homomeric GABA-A receptor rho complexes

Structure

• belongs to the ligand-gated ionic channel (TC 1.A.9) family

Compartment

• cell junction, synapse, postsynaptic cell membrane

Expression

• most abundant in the uterus
• also expressed in lung, thymus & prostate

More general terms

• transmembrane 4e protein
• glycoprotein
• ionotropic receptor subunit

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2568
• OMIM: https://mirror.omim.org/entry/602729
• UniProt: http://www.uniprot.org/uniprot/O00591.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2568