Abhydrolase domain-containing protein 4 (lyso-N-acylphosphatidylethanolamine lipase, alpha/beta-hydrolase 4, ABHD4)

Function

• lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE)
• contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 & sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis
• hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains
• no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine & lysophosphatidylserine

Structure

• belongs to the peptidase S33 family
• Thr-291 is present instead of the conserved His which is expected to be an active site residue

More general terms

• lipase
• abhydrolase domain-containing protein (ABHD)

Database

• UniProt: http://www.uniprot.org/uniprot/Q8TB40.html