late cornified envelope protein 3C; late envelope protein 15; small proline-rich-like epidermal differentiation complex protein 3A (LCE3C, LEP15, SPRL3A)

Function

• precursors of the cornified envelope of the stratum corneum

Structure

belongs to the LCE family

Expression

• skin-specific
• expressed in adult trunk skin, adult arm skin, fetal skin, penile skin, vulva, esophagus, tongue
• not expressed in the cervix, rectum, lung, colon, placenta

Pathology

• deletion of the late cornified envelope LCE3B & LCE3C genes may be susceptibility factors for psoriasis

Genetics

• gene belongs to the LCE cluster present on 1q21

More general terms

• late cornified envelope protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=353144
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:353144
• OMIM: https://mirror.omim.org/entry/612615
• UniProt: http://www.uniprot.org/uniprot/Q5T5A8.html