K+ channel tetramerisation domain-containing protein 12; pfetin, BTB/POZ domain-containing protein KCTD12; predominantly fetal expressed T1 domain, (KCTD12, C13orf2, KIAA1778, PFET1)

Function

• auxiliary subunit of GABA-B receptors
  • determines kinetics of the GABA-B receptor response
• increases agonist potency & markedly alter the G-protein signaling of GABA-B receptors by accelerating onset & promoting desensitization
• interacts as a tetramer with GABRB1 & GABRB2

Compartment

• cell junction, synapse, presynaptic cell membrane, postsynaptic cell membrane

Expression

• expressed in fetal organs
• highest expression levels in cochlea & brain
• expressed in very low levels in adult tissues, brain, lung

More general terms

• K+ channel tetramerisation domain-containing protein (KCTD)
• BTB/POZ domain containing protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=115207
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:115207
• OMIM: https://mirror.omim.org/entry/610521
• UniProt: http://www.uniprot.org/uniprot/Q96CX2.html