tudor domain-containing protein 5 (TDRD5)

Function

• repression transposable elements & prevention their mobilization during spermatogenesis
• probably acts via piRNA through complexes of piRNAs & Piwi proteins governing methylation & subsequent repression of transposons
• required for chromatoid body (CB) assembly (putative)

Structure

• belongs to the TDRD5 family
• contains 3 HTH OST-type domains
• contains 1 Tudor domain

Compartment

• cytoplasm (putative)
• localizes to chromatoid body & pi-body (putative)

Alternative splicing

named isoforms=2

More general terms

• tudor domain-containing protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=163589
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:163589
• UniProt: http://www.uniprot.org/uniprot/Q8NAT2.html