Fibronectin type 3 domain-containing protein 1 (expressed in synovial lining protein, activation-associated cDNA protein, FNDC1, FNDC2, KIAA1866, MEL4B3)

Function

• activator of G protein signaling (putative)

Structure

contains 5 fibronectin F3 modues

Alternative splicing

named isoforms=4

Expression

• isoform 4 is almost absent from healthy skin, barely detectable in benign melanocytic nevi

Pathology

• induced by TGF-beta present in melanoma cell conditioned medium
• expressed in the stroma close to skin tumors, in the tumor cells themselves & in the epidermis of psoriasis

More general terms

• fibronectin type-3 domain-containing protein (FNDC)

Database

• UniProt: http://www.uniprot.org/uniprot/Q4ZHG4.html