Amelogenin, Y isoform (AMELY AMGL AMGY)

Function

• role in biomineralization
• seems to regulate formation of crystallites during the secretory stage of tooth enamel development
• role in the structural organization & mineralization of developing enamel (putative)
• amelogenin is the predominant protein in developing dental enamel

Structure

belongs to the amelogenin family

Compartment

• secreted, extracellular space, extracellular matrix

Alternative splicing

named isoforms=2

Expression

• transiently but abundantly expressed by ameloblasts during tooth development.

Genetics

this isoform is encoded on the Y chromosome

More general terms

• amelogenin

Database

• UniProt: http://www.uniprot.org/uniprot/Q99218.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=266
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:266
• OMIM: https://mirror.omim.org/entry/410000