amelogenin, X isoform (AMELX, AMG, AMGX)
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Function
- role in biomineralization
- seems to regulate formation of crystallites during the secretory stage of tooth enamel development
- role in the structural organization & mineralization of developing enamel (putative)
- amelogenin is the predominant protein in developing dental enamel
Structure
belongs to the amelogenin family
Compartment
Alternative splicing
named isoforms=3 additional isoforms seem to exist
Expression
- transiently but abundantly expressed by ameloblasts during tooth development
Pathology
- defects in AMELX are the cause of amelogenesis imperfecta hypoplastic type 1
Genetics
encoded on the X chromosome