sterile alpha motif domain-containing protein 8; sphingomyelin synthase-related protein 1; SMSr; ceramide phosphoethanolamine synthase; CPE synthase; SAM domain-containing protein 8 (SAMD8)

Function

• endoplasmic reticulum transferase
• has no sphingomyelin synthase activity
• can convert phosphatidylethanolamine & ceramide to ceramide phosphoethanolamine with low yield
• appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum
• seems to be critical for the integrity of the early secretory pathway

Structure

• the SAM domain is required to retain SMAD8 in the endoplasmic reticulum
• belongs to the sphingomyelin synthase family
• contains 1 SAM (sterile alpha motif) domain

Compartment

• endoplasmic reticulum membrane; multi-pass membrane protein

Alternative splicing

named isoforms=2

More general terms

• sterile alpha motif domain-containing protein (SAMD)
• transmembrane 6 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=142891
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:142891
• OMIM: https://mirror.omim.org/entry/611575
• UniProt: http://www.uniprot.org/uniprot/Q96LT4.html