thioredoxin domain-containing protein 6; thioredoxin-like protein 2; Txl-2 (TXNDC6, TXL2, NME9)

Function

• may be a regulator of microtubule physiology monomer & homodimer

no detectable enzyme activity

Structure

• belongs to the NDK family
• contains 1 thioredoxin domain

Compartment

• cytoplasm (putative)
• cytoskeleton (putative)
• associated with microtubules detected in cilia of lung epithelium, & associated with the spermatid tail & manchette (putative)

Alternative splicing

named isoforms=3

Expression

• detected at very low levels in testis, lung & brain

More general terms

• thioredoxin domain-containing protein

Additional terms

• glutaredoxin-3; PKC-interacting cousin of thioredoxin; PICOT; PKC-theta-interacting protein; PKCq-interacting protein; thioredoxin-like protein 2 (GLRX3, PICOT, TXNL2, HUSSY-22)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=347736
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:347736
• UniProt: http://www.uniprot.org/uniprot/Q86XW9.html