arylformamidase (kynurenine formamidase, KF, AFMID)

Function

• catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the 2nd step in the conversion of tryptophan to nicotinic acid, NADH & NADPH
• required for elimination of toxic metabolites (putative)
• kynurenin pathway

N-formyl-L-kynurenine + H2O <--> formate + L-kynurenine

Structure

belongs to the AB hydrolase superfamily

Compartment

• cytoplasm, nucleus
• predominantly cytosolic, some fraction is nuclear

More general terms

• AB hydrolase superfamily

Additional terms

• kynurenine pathway

Database

• UniProt: http://www.uniprot.org/uniprot/Q63HM1.html