myosin-binding protein C, fast-type; Fast MyBP-C; C-protein, skeletal muscle fast isoform (MYBPC2, MYBPCF)

Function

• thick filament-associated protein located in the crossbridge region of vertebrate striated muscle A-bands
• in vitro, MYBPC2 binds MHC, F-actin & native thin filaments, & modifies the activity of actin-activated myosin ATPase
• MYBPC2 may modulate muscle contraction or may play a more structural role

Structure

• belongs to the immunoglobulin superfamily, MyBP family
• contains 3 fibronectin F3 modules
• contains 7 Ig-like C2-type domains

More general terms

• immunoglobulin superfamily protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4606
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4606
• OMIM: https://mirror.omim.org/entry/160793
• UniProt: http://www.uniprot.org/uniprot/Q14324.html