FMRFamide-related peptide; neuropeptide VF (NPVF, C7orf9, RFRP)

Introduction

3 peptides derived from common precursor, FMRFamide-related peptides precursor

• neuropeptide RFRP-1 (neuropeptide NPSF)
• neuropeptide RFRP-2
• neuropeptide RFRP-3 (neuropeptide NPVF)

Function

• neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis & secretion
• neuropeptide RFRP-1 & RFRP-3 inhibit forskolin-induced cAMP formation.
  • RFRP-2 has no inhibitory activity
• neuropeptide RFRP-1 induces secretion of prolactin in rats
• neuropeptide RFRP-3 blocks morphine-induced analgesia

Structure

• belongs to the FARP (FMRFamide related peptide) family

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• isoform 1 is specifically expressed in the retina
• neuropeptides RFRP-1 & RFRP-3 are detected in hypothalamus

More general terms

• neuropeptide

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64111
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64111
• UniProt: http://www.uniprot.org/uniprot/Q9HCQ7.html