testis-specific serine/threonine protein kinase 1; TSK-1; TSK1; TSSK-1; testis-specific kinase 1; serine/threonine protein kinase 22A (TSSK1B, SPOGA1, SPOGA4, STK22A, STK22D ,TSSK1, FKSG81)

Function

• testis-specific serine/threonine protein kinase
• required during spermatid development
• phosphorylates Ser-288 of TSKS
• role in late stages of spermatogenesis, during the reconstruction of the cytoplasm
• during spermatogenesis, required for transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body
• activated by phosphorylation on Thr-174 & potentially by autophosphorylation
• autophosphorylated
• interacts with TSSK2

Cofactor: Mg+2 (putative)

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family
• contains 1 protein kinase domain

Compartment

• cytoplasm
• cytoplasmic vesicle, secretory vesicle
• acrosome (putative)
• cell projection, cilium, flagellum (putative)
• in spermatozoa, present in the sperm head & in the flagellum

Expression

• testis-specific; present in sperm (at protein level)

Pharmacology

• TSSK1B might be used as a target for male contraception &/or intra-vaginal spermicides (Pubmed:17566264)

More general terms

• serine/threonine protein kinase 22

Additional terms

• DiGeorge syndrome; velocardiofacial syndrome; pharyngeal pouch syndrome

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83942
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83942
• OMIM: https://mirror.omim.org/entry/610709
• UniProt: http://www.uniprot.org/uniprot/Q9BXA7.html