dual specificity protein phosphatase 12 (dual-specificity tyrosine phosphatase YVH1, DUSP12)

Function

• dual-specificity phosphatase

protein tyrosine phosphate + H2O
              <-->
protein tyrosine + phosphate

phosphoprotein + H2O <--> a protein + phosphate

Cofactor: binds 2 Zn+2 per subunit

Structure

• belongs to the protein-tyrosine phosphatase family non-receptor class dual specificity subfamily
• contains 1 tyrosine-protein phosphatase domain

Compartment

nucleus

Expression

• ubiquitous, highest expression in spleen, testis, ovary, & peripheral blood leukocytes & lower expression in liver & lung

More general terms

• dual specificity phosphatase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1126
• OMIM: https://mirror.omim.org/entry/604835
• UniProt: http://www.uniprot.org/uniprot/Q9UNI6.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11266