cytosolic phospholipase A2 gamma; cPLA2-gamma; phospholipase A2 group IVC (PLA2G4C)

Function

• preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid
• not regulated by Ca+2

phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate

Kinetic parameters:

• Vmax=218 pmol/min/mg enzyme

Structure

contains 1 PLA2c domain

Compartment

membrane; lipid-anchor

Expression

highly expressed in heart & skeletal muscle

More general terms

• phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8605
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8605
• OMIM: https://mirror.omim.org/entry/603602
• UniProt: http://www.uniprot.org/uniprot/Q9UP65.html