dipeptidyl peptidase 9 (DP9, dipeptidyl peptidase-like protein 9, DPLP9, dipeptidyl peptidase 4-related protein 2, DPRP-2, DPP9, DPRP2)

Function

• dipeptidyl peptidase
• cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2
• release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline

Inhibition:

• serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF)
• di-isopropylfuorophosphate

Kinetic parameters:

• KM=161 uM for Ala-Pro-AMC;
• KM=180 uM for Ala-Pro-AFC;
• Optimum pH is 7.5-8.5, little activity below pH 6.5

Compartment

cytoplasm

Alternative splicing

named isoforms=5

Expression

• ubiquitously expressed
• highest levels in liver, heart, muscle
• lowest levels in brain

More general terms

• dipeptidyl peptidase (DPP)

Database

• OMIM: https://mirror.omim.org/entry/608258
• UniProt: http://www.uniprot.org/uniprot/Q86TI2.html