bleomycin hydrolase; BLM hydrolase (BMH, BH, BLMH)

Function

• normal physiological role of BLM hydrolase is unknown
• catalyzes the inactivation of the antitumor drug bleomycin (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal & malignant cells from bleomycin toxicity (putative)
• inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity
• specificity varies somewhat with source, but amino acid arylamides of Met, Leu & Ala are preferred

Structure

• homohexamer
• belongs to the peptidase C1 family

Compartment

cytoplasm

More general terms

• cysteine proteinase; thiol proteinase

Additional terms

• bleomycin (Blenoxane)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:642
• OMIM: https://mirror.omim.org/entry/602403
• OMIM: https://mirror.omim.org/entry/602403
• UniProt: http://www.uniprot.org/uniprot/Q13867.html