homeobox protein prophet of pit-1; PROP-1; pituitary-specific homeodomain factor (PROP1)

Function

• possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes & caudomedial thyrotropes

Structure

• belongs to the paired homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (putative)

Expression

• expressed specifically in embryonic pituitary

Pathology

• defects in PROP1 are a cause of pituitary hormone deficiency combined type 2

More general terms

• homeobox protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5626
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5626
• OMIM: https://mirror.omim.org/entry/262600
• OMIM: https://mirror.omim.org/entry/601538
• UniProt: http://www.uniprot.org/uniprot/O75360.html