paired mesoderm homeobox protein 2; paired-related homeobox protein 2; PRX-2 (PRRX2, PMX2, PRX2)

Function

• may play a role in the scarless healing of cutaneous wounds during the first two trimesters of development

Structure

• belongs to the paired homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (putative)

Expression

• expressed in fetal skin
  • highest expression found in cells of mesodermal origin within the dermal papilla of the developing hair shaft
  • not detected in epidermis or dermis
• expressed in adult skin
  • weakly expressed within the basal layers of the epidermis
  • not expressed in dermis
• higher expression in fetus than in adult

More general terms

• homeobox protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51450
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51450
• OMIM: https://mirror.omim.org/entry/604675
• UniProt: http://www.uniprot.org/uniprot/Q99811.html