homeobox prospero-like protein PROX1; prospero-related homeobox 1 (PROX1)

Function

• may play a fundamental role in early development of CNS
• may regulate gene expression & development of postmitotic undifferentiated young neurons (putative)

Structure

• belongs to the prospero homeobox family
• contains 1 prospero-type homeobox DNA-binding domain

Compartment

nucleus (probable)

Expression

• most actively expressed in the developing lens
• detected in embryonic brain, lung, liver & kidney
• in adult, expressed in heart & liver > brain, skeletal muscle, kidney & pancreas

More general terms

• homeobox protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5629
• OMIM: https://mirror.omim.org/entry/601546
• UniProt: http://www.uniprot.org/uniprot/Q92786.html