homeobox protein goosecoid-like; GSC-2; homeobox protein goosecoid-2 (GSC2, GSCL)

Function

• may have a role in development
• may regulate its own transcription
• may bind the bicoid consensus sequence TAATCC

Structure

• belongs to the paired homeobox family, Bicoid subfamily
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (putative)

Expression

• detected in adult testis & pituitary, & in 9-10 week fetal tissue (thorax)
• probably expressed in other tissues at low levels
• expressed in early human development as well as in a limited number of adult tissues

Pathology

• may play a part in the etiology of DiGeorge syndrome

More general terms

• homeobox protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2928
• OMIM: https://mirror.omim.org/entry/601845
• UniProt: http://www.uniprot.org/uniprot/O15499.html