distal-less homeobox protein-3; homeobox protein DLX-3 (DLX3)

Function

• likely to play a regulatory role in the development of the ventral forebrain
• may play a role in craniofacial patterning & morphogenesis

Structure

• belongs to the distal-less homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (putative)

Pathology

• defects in DLX3 are a cause of
  • trichodentoosseous syndrome
  • amelogenesis imperfecta

More general terms

• distal-less homeobox protein (DLX)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1747
• OMIM: https://mirror.omim.org/entry/104510
• OMIM: https://mirror.omim.org/entry/190320
• OMIM: https://mirror.omim.org/entry/600525
• UniProt: http://www.uniprot.org/uniprot/O60479.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1747