ATP-binding cassette sub-family C member 10 (multidrug resistance-associated protein 7, CFTR/MRP, ABCC10, MRP7, SIMRP7)

Function

• ATP-dependent transporter
• role in cellular detoxification through lipophilic anion extrusion

Kinetic parameters:

• KM=57.8 uM for 17beta-estradiol 17-(beta-D-glucuronide)
• Vmax=20 pmol/min/mg enzyme toward 17beta-estradiol 17-(beta-D- glucuronide) (at 37 degrees Celsius)

Structure

• belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily
• contains 2 ABC transmembrane type-1 domains
• contains 2 ABC transporter domains Compatment: cell membrane

Alternative splicing

named isoforms=3

Expression

• isoform 1 is specifically expressed in spleen isoform 2 is more widely expressed

More general terms

• ATP-binding cassette sub-family C (ABC transporter-C, ABCC)

Database

• UniProt: http://www.uniprot.org/uniprot/Q5T3U5.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=89845