multidrug resistance-associated protein 6; ATP-binding cassette sub-family C member 6; anthracycline resistance-associated protein; multi-specific organic anion transporter E; MOAT-E (ABCC6 ARA MRP6)

Function

• may participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly
• transports glutathione conjugates including leukotriene-C4 (LTC4) & N-ethylmaleimide S-glutathione (NEM-GS)

Structure

• belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily
• contains 2 ABC transmembrane type-1 domains; residues 311-593 & 947-1228
• contains 2 ABC transporter domains; residues 629-853 & 1265-1499

Compartment

membrane

Expression

• expressed in kidney & liver
• very low expression in other tissues

Pathology

• defects in ABCC6 are the cause of pseudoxanthoma elasticum

More general terms

• transmembrane 17 protein
• ATP-binding cassette sub-family C (ABC transporter-C, ABCC)
• phosphoprotein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/177850
• OMIM: https://mirror.omim.org/entry/264800
• OMIM: https://mirror.omim.org/entry/603234
• UniProt: http://www.uniprot.org/uniprot/O95255.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=368