ATP-binding cassette sub-family A member 6 (ABCA6)

Function

• transporter
• role in macrophage lipid homeostasis (putative)

Structure

• belongs to the ABC transporter family, ABCA subfamily
• contains 2 ABC transporter domains

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• widely expressed with higher expression in liver
• expressed in fetal kidney, lung & liver
• up-regulated during monocyte differentiation into macrophages
• down-regulated by cholesterol loading of macrophages

More general terms

• transmembrane 14 protein
• ATP-binding cassette sub-family A (ABC transporter-A, ABCA)

Database

• UniProt: http://www.uniprot.org/uniprot/Q8N139.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23460