muscle phosphoglycerate mutase (phosphoglycerate mutase isozyme M, PGAM-M, BPG-dependent PGAM 2, muscle-specific phosphoglycerate mutase, PGAM2 PGAMM, PGAM-M)

Function

• interconversion of 3-phosphoglycerate & 2-phosphoglycerate with 2,3-bisphosphoglycerate as a primer
• also synthase & phosphatase activity, albeit diminished

2-phospho-D-glycerate <--> 3-phospho-D-glycerate

3-phospho-D-glyceroyl phosphate <--> 2,3-bisphospho-D-glycerate

2,3-bisphospho-D-glycerate + H2O
               <-->
3-phospho-D-glycerate + phosphate

Structure

• homodimer
• belongs to the phosphoglycerate mutase family, BPG- dependent PGAM subfamily

Pathology

• defects in PGAM2 associated with PGAMM deficiency

More general terms

• phosphoglycerate mutase

Database

• UniProt: http://www.uniprot.org/uniprot/P15259.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5224
• OMIM: https://mirror.omim.org/entry/261670