GDP-mannose 4,6 dehydratase; GDP-D-mannose dehydratase; GMD (GMDS)

Function

• carbohydrate biosynthesis
  • GDP-L-fucose biosynthesis via de novo pathway
  • GDP-L-fucose from GDP-D-mannose: step 1
• conversion of GDP-D-mannose to GDP-4-keto-6-D-deoxymannose

GDP-mannose  <-->  GDP-4-dehydro-6-deoxy-D-mannose + H2O

Cofactor: NADP

Structure

• belongs to the GDP-mannose 4,6-dehydratase family

More general terms

• hydro-lyase, hydratase or dehydratase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2762
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2762
• OMIM: https://mirror.omim.org/entry/602884
• UniProt: http://www.uniprot.org/uniprot/O60547.html